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    首頁(yè) /診斷試劑 /熱門(mén)腫瘤標志物 /TMB /tTMB-P9(matrix) Reference Standard

    tTMB-P9(matrix) Reference Standard

    CBP80001-9

    產(chǎn)品描述
    產(chǎn)品數據庫
    I. Background

    Tumor mutational burden (TMB) shows great promise as a biomarker for immuno-oncology (I-O) therapy response, but progress is hindered by the lack of a standardized TMB measurement by targeted NGS panels, and an absence of TMB reference materials.

     

    Sample ID

    Description

    Cut off=1%

    Cut off=2%

    Cut off=3%

    Cut off=4%

    Cut off=5%

    DC208D0421

    10%T+90%N

    22.94

    19.72

    16.53

    12.50

    8.41

    DC208D0422

    5%T+95%N

    15.75

    10.50

    5.82

    2.92

    1.37

    DC208D0423

    2%T+98%N

    8.29

    2.12

    0.75

    0.42

    0.21

    DC208D0424

    1%T+99%N

    4.15

    0.95

    0.27

    0.18

    0.09
    500xWES;
    IDT xGenExome Research Panel v1.0捕獲，Target Region 39M, Probe Region 51M;
    HiSeq X-TEN，af選擇0.01 cut off，call突變，再過(guò)濾，然后在按照梯度cut off計算TMB。
    Tumor sample: stage 4, adenocarcinoma Lung, Female
    Normal sample: B lymphoblast from the same individual

     

    計算數據下載：

    DC208D0421.filter.0.01.tag

    DC208D0423.filter.0.01.tag

    DC208D0421.filter.0.02.tag

    DC208D0423.filter.0.02.tag

    DC208D0421.filter.0.03.tag

    DC208D0423.filter.0.03.tag

    DC208D0421.filter.0.04.tag

    DC208D0423.filter.0.04.tag

    DC208D0421.filter.0.05.tag

    DC208D0423.filter.0.05.tag

    DC208D0422.filter.0.01.tag

    DC208D0424.filter.0.01.tag

    DC208D0422.filter.0.02.tag

    DC208D0424.filter.0.02.tag

    DC208D0422.filter.0.03.tag

    DC208D0424.filter.0.03.tag

    DC208D0422.filter.0.04.tag

    DC208D0424.filter.0.04.tag

    DC208D0422.filter.0.05.tag

    DC208D0424.filter.0.05.tag

     
     
     
     
     

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